NFL 2025: Which Teams Have the Highest Win Lines Heading Into the New Season?

The wait is nearly over. On September 4th, the NFL will erupt back onto center stage in an opening-night collision between the defending Super Bowl champion Philadelphia Eagles and their oldest adversaries, the Dallas Cowboys. Fireworks? Guaranteed.

But before even a single whistle blows, Vegas and NFL oddsmakers have already cast their verdict on which teams are destined to define the season. The popular NFL Bodog betting platform currently has the reigning champion and curtain-raising Eagles listed as a +750 contender to successfully go back-to-back this season. However, they do lag behind both the Baltimore Ravens and the Buffalo Bills, with the AFC heavyweights currently listed as the respective +600 and +625 frontrunners.

But what about when it comes to win lines? Well, the bookies have their regular season win projections live ahead of the new campaign getting underway, and they have four teams currently listed clear of the chasing pack. Let's see who they are and whether they can get the job done.

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Philadelphia Eagles (O/U 11.5 Wins)

The story of the reigning champs is one of ruthless execution and a roster that—on the evidence—might somehow be getting better. Philadelphia’s 14-3 march through the regular season in 2024 was a masterclass in controlled chaos: Jalen Hurts reminded the league why he’s elite, generating nearly 3,000 passing yards, 32 total touchdowns, and over 600 yards on the ground. Add in a devastating ground game where newcomer Saquon Barkley tore through defenses for over 2,000 yards, and the Eagles became something close to unstoppable.

But it was the defense that smothered opponents. Jalen Carter continued his meteoric rise, racking up double-digit sacks and anchoring a line that terrorized opposing quarterbacks. Their ball-hawking secondary, led by C.J. Gardner-Johnson - who has since moved on to the Houston Texans - and his league-high six interceptions, consistently turned the tide in high-leverage moments.

Most champions risk roster complacency. Not Philly. The Eagles doubled down in the offseason, securing key starters, carefully layering depth in the secondary, and once again resisting the destructive temptation to “over-fix” what isn’t broken. Critically, they bring back the core that has now rattled off three consecutive 11+ win campaigns. The expectation—internally and across the city—is simple: repeat or bust.

Baltimore Ravens (O/U 11.5 Wins)

Is there a franchise more persistent or perennially dangerous than the Ravens? In 2024, Baltimore’s resume was again playoff-grade: 12-5, six straight seasons with double-digit wins, and yet another year where Lamar Jackson’s singular brilliance propelled the offense and left defensive coordinators grasping at straws.

Jackson remains one of the game’s most unique weapons—an MVP-level threat through the air and on the ground—but what separated last season’s Ravens was a defense that cracked the code on modern football. Top five in most major categories, Baltimore could suffocate opponents with pressure or capitalize with game-shifting picks.

Offseason? Calculated, not flashy. The Ravens targeted explosiveness at wide receiver by bringing in DeAndre Hopkins from the Kansas City Chiefs, adding another vertical threat and further tilting the field for Jackson. The front seven gained grunt with proven NFL run-stuffers. And while coach John Harbaugh and GM Eric DeCosta rarely tip their hand, all their moves point in one direction: dethroning the AFC's elite.

They’ve outpaced their posted win total in two straight seasons and open as the favorites to hoist the Lombardi. Super Bowl or disappointment—there’s no middle ground in Baltimore any longer.

Buffalo Bills (O/U 11.5 Wins)

No franchise continually hovers near the summit only to watch someone else take the prize quite like Buffalo. Five straight years of 11 or more wins, a 13-4 showing in 2024, and the analytical darling of the AFC. Josh Allen, their talisman and reigning MVP, continues to put up numbers reserved for legends: north of 4,200 yards, 29 touchdowns, and his trademark blend of aerial firepower and bulldozing runs.

YOUR 2025 NFL REGULAR SEASON MVP JOSH ALLEN! 🏆🤩#BillsMafia pic.twitter.com/RfAO9V1bXL

— Bodog (@BodogCA) February 7, 2025

But Buffalo is also a case study in “almosts.” Division dominance? Achieved. Playoff heartbreak? Too frequent. Last season, the Chiefs brought to an end their postseason for the fourth time in five years, winning a thrilling AFC Championship game at Arrowhead to further enforce their dominance over the conference. Now, the front office is acutely aware of their shortfalls, duly fortifying the O-line to further insulate Allen, as well as adding weapons out wide, and returning the league’s stingiest secondary by yards per attempt.

Historically, Sean McDermott’s squad never falters in the regular season—they’ve surpassed their preseason win total for an NFL-leading eight consecutive years. And yet, the window feels finite. As always, pressure will be measured not by September headlines, but by January banners. The 2025 target is written on every wall in Buffalo: the Super Bowl or the cycle starts anew.

Kansas City Chiefs (O/U 11.5 Wins)

The bookies are seemingly ignoring a few facts when it comes to listing Kansas City's winline alongside the favorites at 11.5. They are looking past the fact that last season's three-peat hunt came to a brutal end, suffering a disastrous 40-22 loss to the Eagles at Super Bowl LIX in one of the most lopsided big games of all time. They are also conveniently ignoring both Patrick Mahomes and Travis Kelce coming off statistically their worst-ever seasons.

It's clear that the bookies still consider KC as the NFL’s gold standard. Their 15-2 regular season record last term was the best in the league, even if many of those wins came by razor-thin margins. The Chiefs have kept the trenches sturdy, brought in several explosive but unproven receivers, and trusted in the chemistry that’s made Mahomes and Andy Reid the most durable head coach-QB partnership of the era.

Will that be enough to secure them 12 or more wins? Only time will tell.

I (AKA CatBurg) have a lifelong passion for sports, especially football and basketball. I enjoy the thrill and excitement of sports betting and everything in between. My teams are (Packers #GoPackGo) and who I am betting on!